Insta-kill

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An insta-kill is a combat action that immediately defeats a monster regardless of how many hit points it has. Be warned though, bosses and some other special monsters are immune, although they may take some damage instead.

Disintegration

Main article: Yellow ray strategy

Disintegration will automatically kill enemies and force all of their (non-conditional) items to drop. None of these can be used while you have the Everything Looks Yellow effect. See yellow ray strategy for a full list of disintegration sources

Combat Items

Using these items doesn't force item drops like disintegration, but they do not have any cooldown period. Most of these items will instead deal damage when used against enemies it can't insta-kill.

• The Bomb blows up anything.
• Sharpened hubcaps have a small (perhaps 25%) chance of decapitating your foe, even if they don't have a head.
• Boozebombs take care of Orcs.
• An exploding cigar is just an exploding cigar.
• Holy bombs, batman obliterate the Undead.
• A Handsome Devil takes your opponent to Hey Deze and grants a +100% bonus to item drops alongside a +200% bonus to meat drops.
• A space invader will steal all of your opponent's quarters.
• The world's most dangerous birdhouse renders anything less cohesive, including tower monsters. (KOLHS only)
• A power pill lets your Puck Man eat your opponent in one gulp, without spending an adventure.
• A glob of superduperheated metal reduces your foe to ashes, at no adventure cost.
• A nuclear stockpile only works in aftercore during Crimbo of 2015, but it will blast your opponent to fallout, at no adventure cost.
• A replica bat-oomerang knocks out a foe three times a day and is not expended on use, at no adventure cost.
• A droppable microphone will either deal damage or immediately drop your foe, at no adventure cost.

Monster-specific Items

The following items only work on specific monsters or in a single location.

• 4:20 bombs annihilate Hippies.
• An antique hand mirror shatters The Guy Made Of Bees.
• A beehive defeats the wall of skin.
• Bobcat grenades tear Beasts to shreds.
• Boxes of hammers destroy Constructs.
• A cigarette lighter burns any enemy in A Mob of Zeppelin Protesters as well as 5-7 other protesters.
• An electric boning knife deconstructs the wall of bones.
• An opium grenade defeats a pair of burnouts and eliminates two additional pairs in the White Citadel Quest.
• A plus-sized phylactery vanquishes the Gargantulihc.
• A drone self-destruct chip dissolves a liquid metal bugbear. (Bugbear Invasion only)
• A quantum nanopolymer spider web removes a bugbear scientist. (Bugbear Invasion only)
• In the old Sorceress' tower, each of the monsters could be insta-killed by a specific combat item. See this page for a full list of tower monsters and their associated items.
  • • Similarly, a glob of dumb mud would also defeat any tower monster. (Heavy Rains only)
• A scroll of ancient forbidden unspeakable evil eliminates some physically-immune ghosts.
• A Bowl of Scorpions knocks out drunk pygmies, at no adventure cost.
• A glark cable fries any enemy in The Red Zeppelin, at no adventure cost.

Combat Skills

Similar to insta-kill items, these skills do not force item drops like disintegration. In fact, some of them destroy the monster so thoroughly that neither items nor meat will drop.

Skill	Source/Requirements	Cost	Item drop	Meat drop	Adventure cost	Notes
Batter Up!	Seal Clubber wielding a club	5 fury	No	No	Normal	Monster is banished until rollover
Carbohydrate Cudgel	Skill learned from The Machine	30 MP dry noodles	No	No	Normal	Deals a large amount of damage against inapplicable monsters.
Fire the Jokester's Gun	Weapon: The Jokester's gun	None	Yes	Yes	Free	Can be used once per day
Gingerbread Mob Hit	Skill learned from My Life of Crime, a Memoir	30 MP	Yes	Yes	Free	Can be used once per day
Release the Boots	Familiar: Pair of Stomping Boots	None	No	No	Normal	Creates delicious paste (see Release the Boots for paste details) The fight does not give substats. Deals a weight-based amount of damage against inapplicable monsters.
Science! Fight with Rational Thought	Familiar: Intergnat suffix: WITH SCIENCE!	None	No	No	Normal	Grants 11 adventures of Rational Thought
Shattering Punch	Skill learned from training scroll: Shattering Punch	30 MP	Yes	Yes	Free	Can be used three times per day. Deals a large amount of damage against inapplicable monsters.
Trap Ghost	Back item: protonic accelerator pack	None	Yes	Yes	Normal	Can only be used against non-boss ghosts after using Shoot Ghost three times. Grants a bonus of +20 substats
Bifurcating Blow	Challenge Path: Avatar of Boris	10 MP	?	?	Normal	Has a 20 adventure (removable) cooldown counter between uses Deals half their HP in damage against inapplicable monsters.
Bear Hug	Challenge Path: Zombie Slayer Equip: right bear arm and left bear arm	None	?	?	Normal	First ten times per day, insta-kills and adds current foe to your zombie horde
Walk Away From Explosion	Challenge Path: Avatar of Sneaky Pete	30 MP	?	?	Normal	Grants Bored With Explosions for 30 adventures, which banishes the monster and acts as cooldown counter for the skill Deals half their HP in damage against inapplicable monsters.
Lightning Strike	Challenge Path: Heavy Rains	20 bolts of Lightning	Yes	Yes	Free